While the molecular basis of such interactions are being gradually uncovered, at the cellular level many questions remain unanswered. For example, the localisation and role of hair follicle epithelial stem cells remains a subject of debate, as does the function of the dermal sheath component. In embryonic appendage development there is strong evidence for common signalling mechanisms, but the degree to which epithelial mesenchymal communication diverges in different adult appendages remains as yet undiscovered.
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